Regulation of Gene Expression and Synaptic Plasticity

Angel Barco Laboratory

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Publications per year: Angel Barco

2010

Valor LM, Jancic D, Lujan R and Barco A (2010). Ultrastructural and transcriptional profiling of neuropathological misregulation of cAMP-response element binding protein function. Cell Death & Differentiation. In press.

Benito E and Barco A (2010). CREB's control of intrinsic and synaptic plasticity: Implications for CREB-dependent memory models. Trends Neurosci. In press. pubmed

Viosca J, Lopez-Atalaya JP, Olivares R, Eckner R and Barco A (2010). Syndromic features and mild cognitive impairment in mice with genetic reduction of p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology. Neurobiol Dis 37(1):186-94. pubmed

Barco A (2010). La material de los recuerdos: circuitos neuronales y cascadas moleculares. Mente y Cerebro 40 (Jan): 24-33. mente&cerebro Free download pdf


2009

Sanchis-Segura C*, Lopez-Atalaya JP* and Barco A (2009). Selective boosting of transcriptional and behavioral responses to drugs of abuse by histone deacetylase inhibition. Neuropsychopharmacology, Sep 2 [Epub ahead of print]. * Equal contributors. pubmed (Featured article pubmed)

Sanchis-Segura C, Jancic D, Jimenez-Minchan M and Barco A (2009). Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses towards morphine- and morphine withdrawal-related cues. Front Behav Neurosci 3:30 pubmed Open access frontiers

Viosca J *, Lopez de Armentia M *, Jancic D and Barco A (2009). Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory. Learn Mem 16(3): 193-197. pubmed * Equal contributors

Viosca J, Malleret G, Bourtchouladze R, Benito E, Vronskava S, Kandel ER and Barco A (2009). Chronic enhancement of CREB activity in the hippocampus interferes with the retrieval of spatial information. Learn Mem 16(3): 198-209 (issue cover). pubmed

Jancic D*, Lopez de Armentia M*, Valor LM, Olivares R and Barco A (2009). Inhibition of cAMP-response element binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration. Cereb Cortex 19(11): 2535-47. * Equal contributors. pubmed

Viosca J, Schuhmacher A, Guerra and Barco A (2009). Germ line expression of H-RasG12V causes neurological deficits associated to Costello syndrome. Genes Brain Behav 8(1): 60-71. pubmed


2008

Barco A, Lopez de Armentia M and Alarcon JM. Synapse-specific stabilization of plasticity processes: The synaptic tagging hypothesis revisited ten years later. Neurosci Biobehav Rev. 32(4):831-51. pubmed

Hawkins RD, Bailey CH, Barco A and Kandel ER (2008). Molecular studies of learning and memory in Aplysia and the hippocampus: A comparative analysis of implicit and explicit memory storage. Chapter in “Learning and memory: A comprehensible reference” (Elsevier Books). elsevier


2007

Lopez de Armentia M, Jancic D, Olivares R, Alarcon ER, Kandel ER and Barco A (2007). CREB-mediated gene expression increases the intrinsic excitability of CA1 pyramidal neurons. J. Neurosci. 27(50): 13909-13918.

Barco A, Jancic D and Kandel ER (2007). CREB-dependent transcription and synaptic plasticity. Chapter in “Regulation of transcription by neuronal activity: To the nucleus and back” (Springer Science publishers). Springer

Barco A and Lopez de Armentia M (2007). El cerebro plástico. Chapter in Unidad didáctica “Viaje al Universo Neuronal” (FECYT). Unidad didactica

Barco A (2007). The Rubinstein-Taybi syndrome: Modeling mental impairment in the mouse. Genes, Brain & Behavior 6(S1):32-39.

2006

Gasic GP, Barco A, Avila J and Lerma J (2006). A meeting to remember: Meeting on memory and related disorders. EMBO Reports 7(8):768-73.

Barco A, Bailey CH and Kandel ER (2006). Common molecular mechanisms in explicit and implicit memory. J. Neurochem. 97(6):1520-33.

Alarcon JM, Barco A and Kandel ER (2006). Capture of L-LTP within and across the apical and basilar dendritic compartments of CA1 pyramidal neurons: synaptic tagging is restricted to specific dendritic compartments. J. Neurosci. 26(1):256-264. 

2005

Barco A and Kandel ER (2005). Role of CREB and CBP in brain function. Chapter in Transcription factors in the nervous system: Development, brain function and disease (Wiley-VCH publishers).

Levine AA, Guan Z, Barco A, Xu S, Kandel ER and Schwartz JH (2005). CREB binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum. Proc Natl Acad Sci U S A. 102(52):19186-91.

Barco A, Patterson S, Alarcon JM, Gromova P, Mata-Roig M, Morozov A and Kandel ER (2005). Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for both the maintenance of LTP and for synaptic capture. Neuron, 48(1): 123-137.

  2004
 

Calandria C, Irurzun A, Barco A and Carrasco L (2004). Individual expression of poliovirus 2APRO induces caspase-3 activation and PARP cleavage in HeLa cells. Virus Research 104(1): 39-49. 

Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel ER and Barco A (2004). Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron 42(6):947-959 (issue cover)   (Featured article pubmed)

Pham TA, Graham SJ, Suzuki S, Barco A, Kandel ER, Gordon B and Lickey ME (2004). A semi-persistent adult ocular dominance plasticity in visual cortex is stabilized by activated CREB. Learning and memory 11(6): 738-747. 

Gao Y, Deng K, Hou J, Bryson JB, Barco A, Nikulina E, Spencer T, Mellado W, Kandel ER and Filbin MT (2004). Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo. Neuron 44(4):609-621. 

Lang C, Barco A, Zablow L, Kandel R, Siegelbaum SA, Zakharenko S (2004). Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation. Proc Natl Acad Sci U S A. 101(47):16665-70. 

 
 
  2003
  Barco A, Pittenger C and Kandel ER (2003). CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects. Expert Opinion on Therapeutic Targets 7(1):101-14. 
  2002
  Barco A, Alarcon JM and Kandel ER (2002) Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108(5):689-703. 

Agirre A, Barco A, Carrasco L and Nieva JL (2002) Viroporin-mediated membrane permeabilization: pore formation by non-structural poliovirus 2B protein. J. Biol. Chem. 277(43):40434-40441. 

Carrasco L, Guinea R, Irurzun A and Barco A. (2002) Effects of viral replication on cellular membrane metabolism and function. Chapter in "Molecular Biology of Picornavirus" edited by B.L. Semler and E. Wimmer (ASM Press) 
  2000
  Barco A, Feduchi E and Carrasco L. (2000) Poliovirus Protease 3C(pro) Kills Cells by Apoptosis. Virology. 266:352-360.  

Barco A, Feduchi E and Carrasco L. (2000) A stable HeLa cell line that inducibly expresses poliovirus 2Apro: effects on cellular and viral gene expression. J. Virol.74: 2383-2392.
  1999
 
Ventoso I, Barco A and Carrasco L. (1999) Genetic selection of poliovirus 2Apro-binding peptides. J Virol. 73:814-818. 
  1998
  Barco A. and Carrasco L. (1998) Identification of regions involved in cytotoxicity in poliovirus 2BC protein. J. Virol. 72: 3560-3570.. 

Barco A. and Carrasco L. (1998) Co-expression of human eIF-4G and poliovirus 2Apro in Saccharomyces cereviseae Effects on gene expression. J. Gen. Virol. 79:2651-60. 

Ventoso I, Barco A and Carrasco L. (1998) Mutational analysis of poliovirus 2Apro distinct inhibitory functions of 2Apro on translation and transcription. J. Biol. Chem. 273:27960-27967. 
  1997
  Barco A, Ventoso I and Carrasco L. (1997). The yeast Saccharomyces cerevisiae as a genetic system for obtaining variants of poliovirus protease 2A. J. Biol. Chem. 272: 12683-12691. 
  1996
  Aldabe R, Barco A and Carrasco L. (1996). Membrane permeabilization by poliovirus protein 2B and 2BC. J. Biol. Chem. 271: 23134-23137. 
  1995
  Barco A and Carrasco L. (1995). Cloning and inducible synthesis of poliovirus non-structural proteins in Saccharomyces cerevisiae. Gene. 156: 19-25. 

Barco A and Carrasco L. (1995). A human virus protein, poliovirus protein 2BC, induces membrane proliferation and blocks the exocytic pathway in the yeast Saccharomyces cereviseae. The EMBO J. 14: 3349-3364. 

Barco A and Carrasco L. (1995). Poliovirus 2Apro expression inhibits growth of yeast cells. FEBS Letters 371: 4-8.