| |
|
| |
 |
|
Publications per year: Angel Barco |
|
2010 |
|
Valor LM, Jancic D, Lujan R and Barco A (2010). Ultrastructural and transcriptional profiling of neuropathological misregulation of cAMP-response element binding protein function. Cell Death & Differentiation. In press.
Benito E and Barco A (2010). CREB's control of intrinsic and synaptic plasticity: Implications for CREB-dependent memory models. Trends Neurosci. In press. 
Viosca J, Lopez-Atalaya JP, Olivares R, Eckner R and Barco A (2010). Syndromic features and mild cognitive impairment in mice with genetic reduction of p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology. Neurobiol Dis 37(1):186-94. 
Barco A (2010). La material de los recuerdos: circuitos neuronales y cascadas moleculares. Mente y Cerebro 40 (Jan): 24-33. Free download  |
|
2009 |
|
Sanchis-Segura C*, Lopez-Atalaya JP* and Barco A (2009). Selective boosting of transcriptional and behavioral responses to drugs of abuse by histone deacetylase inhibition. Neuropsychopharmacology, Sep 2 [Epub ahead of print]. * Equal contributors. (Featured article )
Sanchis-Segura C, Jancic D, Jimenez-Minchan M and Barco A (2009). Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses towards morphine- and morphine withdrawal-related cues. Front Behav Neurosci 3:30 Open access 
Viosca J *, Lopez de Armentia M *, Jancic D and Barco A (2009). Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory. Learn Mem 16(3): 193-197. * Equal contributors
Viosca J, Malleret G, Bourtchouladze R, Benito E, Vronskava S, Kandel ER and Barco A (2009). Chronic enhancement of CREB activity in the hippocampus interferes with the retrieval of spatial information. Learn Mem 16(3): 198-209 (issue cover). 
Jancic D*, Lopez de Armentia M*, Valor LM, Olivares R and Barco A (2009). Inhibition of cAMP-response element binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration. Cereb Cortex 19(11): 2535-47. * Equal contributors. 
Viosca J, Schuhmacher A, Guerra and Barco A (2009). Germ line expression of H-RasG12V causes neurological deficits associated to Costello syndrome. Genes Brain Behav 8(1): 60-71.  |
|
2008 |
|
Barco A, Lopez de Armentia
M and Alarcon JM. Synapse-specific stabilization of plasticity
processes: The synaptic tagging hypothesis revisited ten years later.
Neurosci Biobehav Rev. 32(4):831-51. 
Hawkins RD, Bailey CH, Barco A and Kandel ER (2008). Molecular studies
of learning and memory in Aplysia and the hippocampus: A comparative
analysis of implicit and explicit memory storage. Chapter in “Learning
and memory: A comprehensible reference” (Elsevier Books).  |
|
2007 |
|
Lopez de Armentia M,
Jancic D, Olivares R, Alarcon ER, Kandel ER and Barco A (2007).
CREB-mediated gene expression increases the intrinsic excitability of
CA1 pyramidal neurons. J. Neurosci. 27(50): 13909-13918.
Barco A, Jancic D and Kandel ER (2007). CREB-dependent transcription
and synaptic plasticity. Chapter in “Regulation of transcription by
neuronal activity: To the nucleus and back” (Springer Science
publishers). 
Barco A and Lopez de Armentia M (2007). El cerebro plástico.
Chapter in Unidad didáctica “Viaje al Universo Neuronal”
(FECYT). 
Barco A (2007). The
Rubinstein-Taybi syndrome: Modeling
mental impairment in the mouse. Genes, Brain & Behavior 6(S1):32-39. |
|
2006 |
|
Gasic GP, Barco A, Avila J
and Lerma J (2006). A meeting to remember:
Meeting on memory and related disorders. EMBO Reports 7(8):768-73. 
Barco A, Bailey CH and Kandel ER (2006). Common molecular mechanisms in
explicit and implicit memory. J. Neurochem. 97(6):1520-33. 
Alarcon JM, Barco A and
Kandel ER (2006). Capture of L-LTP within and
across the apical and basilar dendritic compartments of CA1 pyramidal
neurons: synaptic tagging is restricted to specific dendritic
compartments. J. Neurosci. 26(1):256-264.  |
|
2005 |
|
Barco A and Kandel ER
(2005). Role of CREB and CBP in brain function. Chapter in
Transcription factors in the nervous system: Development, brain
function and disease (Wiley-VCH publishers). 
Levine AA, Guan Z, Barco A, Xu S, Kandel ER and Schwartz
JH (2005).
CREB binding protein controls response to cocaine by acetylating
histones at the fosB promoter in the mouse striatum. Proc Natl Acad Sci
U S A. 102(52):19186-91.
Barco A, Patterson S, Alarcon JM, Gromova P, Mata-Roig
M, Morozov A and
Kandel ER (2005). Gene expression profiling of facilitated L-LTP in
VP16-CREB mice reveals that BDNF is critical for both the maintenance
of LTP and for synaptic capture. Neuron, 48(1): 123-137. |
| |
2004 |
| |
Calandria C, Irurzun A, Barco A and Carrasco L (2004).
Individual expression of poliovirus 2APRO induces caspase-3 activation
and PARP cleavage in HeLa cells. Virus Research 104(1): 39-49. 
Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S,
Kandel ER and Barco A (2004). Chromatin acetylation, memory, and LTP
are impaired in CBP+/- mice: a model for the cognitive deficit in
Rubinstein-Taybi syndrome and its amelioration. Neuron
42(6):947-959 (issue cover) (Featured article )
Pham TA, Graham SJ, Suzuki S, Barco A, Kandel ER, Gordon
B and Lickey ME (2004). A semi-persistent adult ocular dominance
plasticity in visual cortex is stabilized by activated CREB. Learning
and memory 11(6): 738-747. 
Gao Y, Deng K, Hou J, Bryson JB, Barco A, Nikulina E,
Spencer T, Mellado W, Kandel ER and Filbin MT (2004). Activated CREB is
sufficient to overcome inhibitors in myelin and promote spinal axon
regeneration in vivo. Neuron 44(4):609-621. 
Lang C, Barco A, Zablow L, Kandel R, Siegelbaum SA,
Zakharenko S (2004). Transient expansion of synaptically connected
dendritic spines upon induction of hippocampal long-term potentiation.
Proc Natl Acad Sci U S A. 101(47):16665-70.  |
| |
| |
| |
2003 |
| |
Barco A, Pittenger C and Kandel ER (2003).
CREB, memory enhancement and
the treatment of memory disorders: promises, pitfalls and prospects.
Expert Opinion
on Therapeutic Targets 7(1):101-14.  |
| |
2002 |
| |
Barco A, Alarcon JM and Kandel ER (2002)
Expression of constitutively active CREB protein facilitates the late
phase of long-term potentiation by enhancing
synaptic capture. Cell 108(5):689-703. 
Agirre A, Barco A, Carrasco L and Nieva JL (2002) Viroporin-mediated
membrane permeabilization: pore formation by non-structural poliovirus
2B protein.
J. Biol. Chem. 277(43):40434-40441. 
Carrasco L, Guinea R, Irurzun A and Barco A. (2002) Effects of viral
replication on cellular membrane metabolism and function. Chapter in
"Molecular
Biology of Picornavirus" edited by B.L. Semler and E. Wimmer (ASM
Press)  |
| |
2000 |
| |
Barco A, Feduchi E and Carrasco L. (2000)
Poliovirus Protease 3C(pro)
Kills Cells by Apoptosis. Virology. 266:352-360. 
Barco A, Feduchi E and Carrasco L. (2000) A stable HeLa cell line that
inducibly expresses poliovirus 2Apro: effects on cellular and viral
gene expression.
J. Virol.74: 2383-2392. |
| |
1999 |
| |
Ventoso I, Barco A and Carrasco L. (1999) Genetic selection of
poliovirus
2Apro-binding peptides. J Virol. 73:814-818.  |
| |
1998 |
| |
Barco A. and Carrasco L. (1998)
Identification of regions involved in
cytotoxicity in poliovirus 2BC protein. J. Virol. 72: 3560-3570.. 
Barco A. and Carrasco L. (1998) Co-expression of human eIF-4G and
poliovirus
2Apro in Saccharomyces cereviseae Effects on gene expression. J. Gen.
Virol.
79:2651-60. 
Ventoso I, Barco A and Carrasco L. (1998) Mutational analysis of
poliovirus
2Apro distinct inhibitory functions of 2Apro on translation and
transcription.
J. Biol. Chem. 273:27960-27967.  |
| |
1997 |
| |
Barco A, Ventoso I and Carrasco L. (1997).
The yeast Saccharomyces cerevisiae as a genetic system for obtaining
variants of poliovirus protease 2A. J. Biol.
Chem. 272: 12683-12691.  |
| |
1996 |
| |
Aldabe R, Barco A and Carrasco L. (1996).
Membrane permeabilization by
poliovirus protein 2B and 2BC. J. Biol. Chem. 271: 23134-23137.  |
| |
1995 |
| |
Barco A and Carrasco L. (1995). Cloning
and inducible synthesis of poliovirus non-structural proteins in
Saccharomyces cerevisiae. Gene. 156: 19-25. 
Barco A and Carrasco L. (1995). A human virus protein, poliovirus
protein
2BC, induces membrane proliferation and blocks the exocytic pathway in
the yeast
Saccharomyces cereviseae. The EMBO J. 14: 3349-3364. 
Barco A and Carrasco L. (1995). Poliovirus 2Apro expression inhibits
growth of yeast cells. FEBS Letters 371: 4-8.  |
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
|