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Research Group
Synaptic Neuromodulation
Unit Unit Cellular and Systems Neurobiology »

Laboratory Web Unit

Principal Investigator
Research Fields
After the intensive refinement process that occurs during the developmental stages, the mature brain retains the ability of undergoing rapid adaptations in response to external stimuli by the means of a cellular phenomenon known as synaptic plasticity. Our goal is to understand how synaptic plasticity is regulated in discrete neural circuits, and how alterations of this process can lead to neurodegenerative and neuropsychiatric diseases. In particular, our laboratory is currently identifying susceptible circuits during early stages of neurodegeneration by using viral-based circuit mapping techniques. We are also interested in understanding how critical neuromodulators such as cathecolamines and endogenous neuropeptides are secreted and how their exocytosis impacts synaptic plasticity and ultimately behavior. To improve the resolution of our molecular studies and manipulations, we plan to develop novel tools to regulate neuronal signaling and function. In particular, we are interested in exploring photo-activatable molecules to control vesicle dynamics in in vivo and in vitro models.

Representative Publications

Ramírez-Franco JJ , Munoz-Cuevas FJ, Luján R, Jurado S. " Excitatory and Inhibitory Neurons in the Hippocampus Exhibit Molecularly Distinct Large Dense Core Vesicles. " Front Cell Neurosci . doi: 10.3389/fncel.2016.00202 , - ( 2016 )

Schwartz N , Temkin P, Jurado S, Lim BK, Polepalli JS, Malenka RC. " Decreased motivation during chronic pain requires galanin-dependent depression of the nucleus accumbens indirect pathway. " Science . 345 , 535 - 42 ( 2014 )

Jurado S , Goswami D, Zhang Y, Südhof TC, Malenka RC. " LTP requires unique postsynaptic SNARE fusion machinery. " Neuron . 77 , 542 - 58 ( 2013 )

Jurado S , Biou V, Malenka RC. " A calcineurin/AKAP complex is required for NMDA receptor dependent-LTD. " Nat Neurosci . 13 , 1053 - 5 ( 2010 )

Jurado S , Benoist M, Lario A, Petrok CM, Esteban JA. " PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. " EMBO J . 29 , 2827 - 40 ( 2010 )
Consejo Superior de Investigaciones Científicas
Universidad Miguel Hernández

Campus de San Juan | Sant Joan d’Alacant
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