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A new model of corticogenesis.

Nature Neuroscience 2013, 16:1199-1210

Gabriel Ciceri, Nathalie Dehorter, Ignasi Sols, Z Josh Huang, Miguel Maravall & Oscar Marín

In the cerebral cortex, pyramidal cells and interneurons are generated in distant germinal zones, and so the mechanisms that control their precise assembly into specific microcircuits remain an enigma. In this study, Gabriele Ciceri and his colleagues at the Instituto de Neurociencias (a join center from the Spanish Research Council CSIC and Universidad Miguel Hernández) report that cortical interneurons labeled at the clonal level do not distribute randomly but rather have a strong tendency to cluster in the mouse neocortex. This behavior is common to different classes of interneurons, independently of their origin. Interneuron clusters are typically contained within one or two adjacent cortical layers, are largely formed by isochronically generated neurons and populate specific layers, as revealed by unbiased hierarchical clustering methods. These results suggest that different progenitor cells give rise to interneurons populating infra- and supragranular cortical layers, which challenges current views of cortical neurogenesis. Thus, specific lineages of cortical interneurons seem to be produced to primarily mirror the laminar structure of the cerebral cortex, rather than its columnar organization.

 

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