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People About the institute Berta López Sánchez-Laorden
Degree:
B.Sc. in Biology, School of Biology, University of Murcia, 2003.
B.Sc. in Biochemistry, School of Chemistry, University of Murcia, 2004.


Ph.D program:
PhD in Biochemistry and Molecular Biology, University of Murcia (2008).

Posdoctoral Positions:
2014/2016: Instituto de Neurociencias CSIC-UMH (San Juan de Alicante, Spain)
2012/2014: Cancer Research UK Manchester Institute (Manchester, UK).
2008/2012: The Institute of Cancer Research (London, UK).


Previous positions:
2016-2017: Ramón y Cajal Investigator


Current Position:
From 2017: Tenured CSIC Scientist.  
Principal Investigator SAF2016-75702-R (Retos Investigación: Proyectos I+D+i 2016, MINECO)


Research Fields:
Cancer development and progression, tumour microenvironment, melanoma, brain metastases


Representative Publications

Grande MT , Sánchez-Laorden B*, López-Blau C, De Frutos CA, Boutet A, Arévalo M, Rowe RG, Weiss SJ, López-Novoa JM, Nieto MA. " Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. " Nature Medicine . 21(9) , 989 - 97 ( 2015 ) *Co-First Author

Smith MP , Sanchez-Laorden B* , O'Brien K, Brunton H, Ferguson J, Young H, Dhomen N, Flaherty KH, Frederick DT , Cooper ZA, Wargo JA, Marais R and Wellbrock C. " The immune-microenvironment confers resistance to MAP kinase pathway inhibitors through macrophage-derived TNFα. " Cancer Discovery . 4(10) , 1214 - 29 ( 2014 ) *Co-First Author

Viros A. , Sanchez-Laorden B*, Pedersen M, Furney SJ, Rae J, Hogan K, Ejiama S, Girotti MR, Cook M, Dhomen N, Marais R. " Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53. " Nature . 511(7510) , 478 - 82 ( 2014 ) *Co-First Author

Sanchez-Laorden B , Viros A, Girotti MR, Pedersen M, Saturno G, Zambon A, Niculescu-Duvaz D, Turajlic S, Hayes A, Gore M, Larkin J, Lorigan P, Cook M, Springer C, Marais R. " MEK/ERK pathway reactivation drives invasion and metastasis in drug-resistant melanoma. " Science Signaling . 7(318) , ra - 30 ( 2014 )

Sanchez-Laorden BL , Jimenez-Cervantes C, Garcia-Borron JC. " Regulation of human melanocortin 1 receptor signaling and trafficking by Thr-308 and Ser-316 and its alteration in variant alleles associated with red hair and skin cancer. " J Biol Chem . 282(5) , 3241 - 5 ( 2007 )
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