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People About the institute Javier Sáez Valero
Degree:
· Degree in Biology, Faculty of Biology, University of Murcia, Spain, 1990.

Ph.D program:
. Ph.D. in Biology , at the Dept. of Biochemistry and Molecular Biology, University of Murcia, 1996.

Posdoctoral Positions:
-Dept. of Pathology, Lab. of Molecular Neurobiology, Melbourne Univ., VIC, Australia (1996-1999)
-Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italia (1999)

Previous positions:
-Research scientist at the IN-UMH/CSIC supported by a MEC return grant  (2000)
-Research scientist at the Hosp. Gral. Univ. Alicante supported by a FIS grant (SNS-MSyC) (2001)

Current Position:
Profesor Contratado Doctor, Dpto. Bioquímica y Biología Molecular, Universidad Miguel Hernández de Elche.

Research Fields:
1. The role of acetylcholinesterase in the pathogenesis, therapy and diagnostic of Alzheimer´s disease.
2. Diagnostic markers for Alzheimer.
3. Reelin in neurodegenerative disorders.
4. Altered expression of cholinesterases in cirrhosis and hepatic encephalopathy


Representative Publications

Silveyra MX. , Evin, G; Montenegro, MF; Vidal, CJ; Martínez, S; Culvenor, J; Sáez-Valero, J. " Presenilin-1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation. " Mol Cell Biol. . 28 , 2908 - 2919 ( 2008 )

Garcia-Ayllon MS. , Silveyra MX.,Andreasen N.,Brimijoin S.,Blennow K.,Saez-Valero J. " Cerebrospinal fluid acetylcholinesterase changes after treatment with donepezil in patients with Alzheimer's disease. " J Neurochem . 101 , 1701 - 1711 ( 2007 )

Garcia-Ayllon MS. , Silveyra MX.,Candela A.,Compañ A.,Claria J.,Jover R.,Perez-Mateo M.,Felipo V.,Martinez S.,Galceran J.,Saez-Valero J. " Changes in liver and plasma acetylcholinesterase of rats with bile duct ligation. " Hepatology . 43 , 444 - 453 ( 2006 )

Botella-Lopez A. , Burgaya, F; Gavin, R; Garcia-Ayllon, MS; Gomez-Tortosa, E; Peña-Casanova, J; Ureña, JM; Del Rio, JA; Blesa, R; Soriano, E; Saez-Valero, J. " Reelin expression and glycosylation patterns are altered in Alzheimer's disease. " Proc Natl Acad Sci USA . 103 , 5573 - 5578 ( 2006 )

Sáez-Valero J. , Sberna G., McLean C.A., Masters C.L., Small D.H. " Glycosylation of acetylcholinesterase as diagnostic marker for Alzheimer’s disease. " The Lancet . 350 , 929 - 929 ( 1997 )
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