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People About the institute Juan Galcerán Sáez
Degree:
Biological Sciences, Universidad de Barcelona, July 1981.

Ph.D program:
PhD thesis with Dr. Marta Izquierdo Rojo at Centro de Biología Molecular Severo Ochoa CSIC-UAM between September 1982 and September 1987. Doctorate in Biological Sciences by Universidad Autónoma de Madrid in October 1987.

Posdoctoral Positions:
Department of Neurogenetics. Instituto Cajal. Madrid in the laboratory of Prof. Alberto Ferrús from 1998 to 1991

Department of Cardiology. Children’s Hospital. Harvard Medical School and Howard Hughes Medical Institute. Boston MA USA In the laboratory of Prof. Bernardo Nadal-Ginard from 1991 to 1995

Department of Microbiology and Immunology and Howard Hughes Medical Institute. UCSF  San Francisco CA USA. In the laboratory of Prof. Rudolf Grosschedl from 1995 to 1999.

Institute of Biochemistry. Gene Center. Ludwig Maximilians University. University of Munich. Munich Germany. Laboratory of Prof. Rudolf Grosschedl from 1999 to 2002.



Previous positions:
Principal investigator of MCYT’s plan Ramón y Cajal between March 2002 and June 2003. At Instituto de Neurociencias CSIC-UMH

Current Position:
Research Scientist “Ramón y Cajal” Program.
Científico Titular CSIC since June 2003.

Research Fields:
Nervous system development, focusing on the transcriptional control of neurogenesis and signalling pathways involved in neurogenesis.

Representative Publications

Hsu, S.C. , Galceran, J. and Grosschedl, R " Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin. " Mol Cell Biol . 18(8) , 4807 - 4818 ( 1998 )

Galceran, J. , Farinas, I.; Depew, M.J.; Clevers, H. and Grosschedl, R. " Wnt3a-l-/-l-like phenotype and limb deficiency in Lef1-l/-Tcf1-l mice. " Genes Dev. . 13(6) , 709 - 717 ( 1999 )

Galceran, J. , Miyashita-lin, E.M.; Devaney, E.; Rubenstein, JL and Grosschedl, R. " Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. " Development . 127(3) , 469 - 482 ( 2000 )

Galceran, J. , Hsu, S.C. and Grosschedl, R. " Rescue of a Wnt mutation by an activated form of LEF-1: Regulation of maintenance but not initiation of Brachyury expression. " Proc. Natl. Acad. Sci. USA . 98(15) , 8668 - 8673 ( 2001 )

Kratochwil, K. , Galceran, J.; Tontsch, S.; Roth, W. and Grosschedl, R. " FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1-/- mice " Genes Dev . 16(24) , 3173 - 3185 ( 2002 )
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